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Cap. Flugal 50 mg

SKU: Cs24309

Fluconazole
50 mg
Square Pharmaceuticals PLC

৳ 72.63৳ 363.15

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Description

Indication:
Used for the treatment of fungal infections, including candidiasis (oral, vaginal, and systemic), cryptococcal meningitis, and dermatomycosis. Also used for fungal infection prophylaxis in immunocompromised patients.

Pharmacology, Dosage & Administration:
Fluconazole is an azole antifungal that inhibits fungal ergosterol synthesis, disrupting the fungal cell membrane.

Usual dose: 50 mg once daily for mild infections, with duration depending on the severity and type of infection.
Can be taken with or without food.

Interaction:
Increases the effects of warfarin, cyclosporine, phenytoin, and oral hypoglycemics, leading to potential toxicity.
Reduces metabolism of benzodiazepines and statins, increasing side effects.
Caution with rifampin as it reduces fluconazole effectiveness.

Contraindications:
Hypersensitivity to fluconazole or other azole antifungals.
Concurrent use with terfenadine or cisapride due to risk of cardiac arrhythmia.

Side Effects:
Common: Nausea, headache, abdominal pain, diarrhea
Rare: Liver toxicity, severe skin reactions (Stevens-Johnson syndrome), QT prolongation

Pregnancy & Lactation:
Pregnancy Category C (single-dose treatment for vaginal candidiasis is considered safe, but prolonged use may cause fetal harm).
Found in breast milk; caution is advised for lactating mothers.

Precautions & Warnings:
Monitor liver function in long-term use.
Use cautiously in patients with renal or hepatic impairment.
Avoid in patients with known QT prolongation or heart disease.

Overdose Effects:
Symptoms include hallucinations, paranoia, nausea, vomiting, and liver toxicity.
Treatment is symptomatic, with supportive care and gastric lavage if necessary.

Therapeutic Class:
Systemic Antifungal (Azole group)

Storage Conditions:
Store below 30°C in a dry place, away from moisture and direct light.
Keep out of reach of children.

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