Tab. Napadol

​Napadol is a combination analgesic tablet formulated to manage moderate to moderately severe pain. Below is a comprehensive overview of its properties and usage guidelines:​

Ingredients:
Paracetamol: 325 mg per tablet.​
Tramadol Hydrochloride: 37.5 mg per tablet.​

Direction of Use:
Dosage: For adults and adolescents aged 12 years and older, the recommended dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief. The maximum dosage should not exceed 8 tablets per day. ​

Indication:
Napadol is indicated for the symptomatic treatment of moderate to severe pain. ​

Pharmacology, Dosage & Administration:
Pharmacology:
Paracetamol: Acts as an analgesic and antipyretic with weak anti-inflammatory properties.​
Tramadol: A centrally acting synthetic opioid analgesic that binds to μ-opioid receptors and inhibits the reuptake of norepinephrine and serotonin, contributing to its pain-relieving effects.​
Administration: Oral administration with or without food. ​

How to Use:
Swallow the tablet whole with a sufficient amount of water. Do not crush or chew the tablet.​

Interaction:
CNS Depressants: Concomitant use with alcohol, anesthetics, narcotics, or sedative hypnotics may enhance CNS depression.​
MAO Inhibitors: Avoid use with monoamine oxidase inhibitors due to potential interactions.​

Contraindications:
Patients with hypersensitivity to paracetamol, tramadol, or any excipients in the formulation.​
Acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic drugs.​

Product Technical Details:
Formulation: Film-coated tablet.​
Packaging: Typically available in blister packs containing 10 tablets.​

Side Effects:
Common: Nausea, dizziness, somnolence, and vomiting.​
MedicinesFAQ
Uncommon: Cardiovascular regulation disturbances (e.g., palpitations, tachycardia), skin reactions (e.g., pruritus, sweating).​

Pregnancy & Lactation:
Pregnancy: Not recommended due to potential risks associated with opioid use.​
Lactation: Tramadol is excreted in breast milk; therefore, its use is not recommended during breastfeeding.​

Precautions & Warnings:
Dependence and Abuse Potential: Tramadol has the potential for dependence; use with caution in patients with a history of substance abuse.​
Seizure Risk: Use cautiously in patients with a history of seizures or those taking medications that lower the seizure threshold.​
Renal and Hepatic Impairment: Dosage adjustments may be necessary; consult prescribing information for guidance.