Tab. Minibet 100 mg

Ingredients:
Ciprofibrate 100 mg

Direction of Use:
Take orally once daily with or after food, or as directed by your physician.
Swallow the tablet whole with water.

Indication:
Treatment of hyperlipidemia, particularly:
Hypertriglyceridemia (Type IV and V dyslipidemia)
Mixed hyperlipidemia (Type IIb)
Familial combined hyperlipidemia
Adjunct to diet and exercise when response to other measures (e.g., weight loss, diet) is inadequate
May be used in patients at risk of pancreatitis due to severe hypertriglyceridemia

Pharmacology:
Ciprofibrate is a fibric acid derivative (fibrate) that works by activating peroxisome proliferator-activated receptors (PPARα). This results in:
Increased oxidation of fatty acids in the liver
Decreased triglyceride synthesis
Increased HDL cholesterol levels
Reduction in VLDL and LDL cholesterol levels
It improves lipid profile and reduces cardiovascular risk in select high-risk patients.

Category:
Lipid-lowering Agent / Fibrate Class

Dosage & Administration:
Usual adult dose: 100 mg once daily, preferably in the evening
Duration of therapy depends on lipid profile response
Regular lipid monitoring is recommended every 3–6 months

How to Use:
Take with food to enhance absorption and reduce gastrointestinal side effects
Take at the same time each day for consistent lipid control
Continue treatment even if lipid levels improve—stopping may reverse the effect
Do not crush or chew the tablet

Interaction:
Statins (e.g., simvastatin, atorvastatin): Increased risk of myopathy or rhabdomyolysis
Oral anticoagulants (e.g., warfarin): Potentiation of anticoagulant effect
Cyclosporine: Risk of nephrotoxicity
Oral antidiabetics or insulin: Enhanced hypoglycemic effect may occur
Avoid alcohol due to liver strain

Contraindications:
Hypersensitivity to ciprofibrate or other fibrates
Severe liver or kidney dysfunction
Gallbladder disease or gallstones
Pregnancy and lactation
Children and adolescents (safety not established)

Product Technical Details:
Form: Film-coated tablet
Strength: Ciprofibrate 100 mg
Route: Oral
Packaging: Blister strip or box of tablets

Side Effects:
Common: Indigestion, abdominal discomfort, nausea, diarrhea
Less common: Muscle pain or weakness, headache, fatigue
Rare but serious: Rhabdomyolysis (muscle breakdown), liver enzyme elevations, gallstones

Pregnancy & Lactation:
Pregnancy: Contraindicated; animal studies show risk, and no adequate human data
Lactation: Not recommended; unknown if excreted in breast milk

Precautions & Warnings:
Monitor liver function tests and renal function during prolonged use
Discontinue immediately if unexplained muscle pain or weakness occurs
Use with caution in elderly patients
Ensure patient follows a low-fat, low-cholesterol diet alongside medication
Not a substitute for lifestyle changes (diet, exercise)

Overdose Effects:
No specific antidote
Symptoms: Gastrointestinal distress, muscle toxicity
Management: Symptomatic treatment and supportive care

Therapeutic Class:
Antilipidemic Agents / Fibrates

Storage Conditions:
Store below 25°C in a dry place
Protect from moisture and direct sunlight
Keep out of reach of children

Disclaimer:
This information is for general educational purposes and should not replace medical advice. Always consult your healthcare provider before starting or discontinuing any medication.