-10%
Ingredients:
Each tablet contains:
Sitagliptin 50 mg
Metformin Hydrochloride 500 mg
Direction of Use:
Take the tablet as prescribed by your doctor, usually with meals to reduce gastrointestinal side effects. Swallow whole; do not crush or chew.
Indication:
Used for the treatment of Type 2 Diabetes Mellitus (T2DM) to improve glycemic control in adults when diet and exercise alone are insufficient.
Pharmacology:
Sitagliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that increases insulin secretion and reduces glucagon levels in response to meals.
Metformin Hydrochloride: A biguanide that decreases hepatic glucose production, improves insulin sensitivity, and enhances glucose uptake by muscles.
Category:
Oral Antidiabetic Combination Therapy
Dosage & Administration:
Usual dose: One tablet twice daily with meals.
Dosage may vary based on the patient’s response and renal function.
Maximum dose: As per doctor’s prescription.
How to Use:
Take the tablet with food to minimize stomach discomfort.
Maintain a regular schedule for optimal blood sugar control.
Do not skip doses or stop abruptly without consulting a doctor.
Interaction:
With other medications: May interact with insulin, sulfonylureas, diuretics, and beta-blockers.
Alcohol: Increases the risk of lactic acidosis and hypoglycemia.
Caution with kidney or liver impairment.
Contraindications:
Hypersensitivity to Sitagliptin or Metformin
Severe renal impairment or kidney disease
Acute metabolic acidosis, including diabetic ketoacidosis
History of lactic acidosis
Product Technical Details:
Form: Film-coated tablet
Strength: 50 mg Sitagliptin + 500 mg Metformin HCl
Route of Administration: Oral
Side Effects:
Common: Nausea, diarrhea, abdominal discomfort, headache
Serious: Lactic acidosis (rare but severe), pancreatitis, hypoglycemia (if combined with insulin or sulfonylureas)
Pregnancy & Lactation:
Pregnancy: Use only if clearly needed and prescribed by a doctor.
Lactation: Not recommended due to potential risks to the infant.
Precautions & Warnings:
Regular kidney function monitoring is necessary.
Avoid excessive alcohol intake.
Stop the medication before undergoing contrast imaging procedures (due to the risk of lactic acidosis).
Overdose Effects:
Symptoms: Lactic acidosis, severe hypoglycemia, weakness, nausea, and dizziness.
Management: Immediate medical attention, supportive care, and symptomatic treatment.
Therapeutic Class:
DPP-4 Inhibitor + Biguanide Combination
Storage Conditions:
Store below 25°C in a dry place, away from moisture and direct sunlight.
Keep out of reach of children.
Disclaimer:
This information is for reference purposes only and should not replace professional medical advice. Always consult your doctor or pharmacist before starting any medication.
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