Tab. Arlin 600 mg

Direction of Use:
Take orally with or without food, exactly as prescribed by your physician.
Do not skip doses and complete the full course, even if symptoms improve.
Do not self-medicate or adjust the dose without medical advice.

Indication:
Treatment of infections caused by Gram-positive bacteria, including:
Community-acquired and nosocomial pneumonia
Skin and soft tissue infections
Vancomycin-resistant Enterococcus faecium (VRE) infections
Methicillin-resistant Staphylococcus aureus (MRSA)
Diabetic foot infections (without osteomyelitis)
Bacteremia due to susceptible organisms

Pharmacology:
Linezolid is an oxazolidinone-class antibiotic. It works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, thereby preventing the formation of the initiation complex essential for translation.
It is bacteriostatic against most organisms but may exhibit bactericidal activity against streptococci.

Category:
Antibiotic – Oxazolidinone class

Dosage & Administration:
Adults: 600 mg every 12 hours for 10–14 days (duration depends on infection type and severity)
Can be taken with or without meals
Dosage adjustments may be needed in patients with severe renal impairment

How to Use:
Swallow the tablet whole with a glass of water
Maintain a consistent schedule (e.g., every 12 hours)
Do not stop treatment prematurely—even if you feel better
Avoid high tyramine foods (e.g., aged cheese, soy sauce) during treatment

Interaction:
MAO Inhibitor-like effect: Avoid concurrent use with SSRIs, SNRIs, tricyclic antidepressants—may cause serotonin syndrome
Adrenergic and serotonergic drugs: Increased risk of hypertensive or serotonergic crisis
Tyramine-rich foods: May cause hypertensive episodes
Rifampin: May reduce Linezolid levels

Contraindications:
Known hypersensitivity to Linezolid
Concomitant use with MAO inhibitors or within 2 weeks of taking them
Patients with uncontrolled hypertension, thyrotoxicosis, or pheochromocytoma
Use with caution in patients with a history of serotonin syndrome

Product Technical Details:
Form: Film-coated tablet

Strength: 600 mg Linezolid
Route: Oral
Packaging: Blister pack or bottle

Side Effects:
Common: Nausea, vomiting, diarrhea, headache, insomnia

Serious:
Myelosuppression (anemia, leukopenia, thrombocytopenia)
Peripheral and optic neuropathy (especially with long-term use)

Lactic acidosis
Serotonin syndrome when combined with serotonergic agents

Pregnancy & Lactation:
Pregnancy: Use only if clearly needed; limited human data
Lactation: Excretion in breast milk unknown—use caution or avoid breastfeeding

Precautions & Warnings:
Monitor CBC weekly in prolonged therapy
Discontinue if myelosuppression or neuropathy occurs
Watch for visual changes with long-term use
Avoid in patients taking serotonergic psychiatric medications unless no alternatives exist
Use caution in patients with liver or renal dysfunction

Overdose Effects:
Symptoms: Nausea, vomiting, CNS disturbances, lactic acidosis
Management: Symptomatic and supportive; hemodialysis may remove some of the drug

Therapeutic Class:
Oxazolidinone Antibiotic

Storage Conditions:
Store below 25°C
Keep in original packaging away from moisture and light
Keep out of reach of children

Disclaimer:
This information is intended for general educational purposes only and should not replace medical advice. Always consult a healthcare professional before starting or stopping any medication.